Normal substantia nigra patients treated with levodopa - Clinical, therapeutic and pathological observations.
Identifieur interne : 000623 ( Main/Exploration ); précédent : 000622; suivant : 000624Normal substantia nigra patients treated with levodopa - Clinical, therapeutic and pathological observations.
Auteurs : Ali H. Rajput [Canada] ; Michele L. Rajput [Canada] ; Christopher A. Robinson [Canada] ; Alex Rajput [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Essential Tremor, Parkinson Disease.
- drug effects : Substantia Nigra.
- pathology : Substantia Nigra.
- Adult, Aged, Aged, 80 and over, Autopsy, Diagnostic Errors, Female, Humans, Male, Middle Aged, Young Adult.
Abstract
Definite diagnosis of idiopathic Parkinson's disease is based on histological findings of marked substantia nigra neuronal loss and Lewy body inclusions. Almost all cases with clinical diagnosis of idiopathic Parkinson's disease are treated with levodopa. Because there is no biological marker for the diagnosis, erroneous clinical diagnosis and treatment of such cases with levodopa are well known. There is very limited literature on levodopa treated cases that had normal substantia nigra at autopsy.
DOI: 10.1016/j.parkreldis.2015.08.029
PubMed: 26372624
Affiliations:
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Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan, Canada. Electronic address: ali.rajput@saskatoonhealthregion.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L" last="Rajput">Michele L. Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A" last="Robinson">Christopher A. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Saskatchewan Movement Disorders Program, Department of Pathology, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Saskatchewan Movement Disorders Program, Department of Pathology, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><nlm:affiliation>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Saskatchewan Movement Disorders Program, Department of Medicine, University of Saskatchewan/Saskatoon Health Region, Saskatoon, Saskatchewan</wicri:regionArea><wicri:noRegion>Saskatchewan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Autopsy</term><term>Diagnostic Errors</term><term>Essential Tremor (diagnosis)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Substantia Nigra (drug effects)</term><term>Substantia Nigra (pathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Autopsy</term><term>Diagnostic Errors</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Definite diagnosis of idiopathic Parkinson's disease is based on histological findings of marked substantia nigra neuronal loss and Lewy body inclusions. Almost all cases with clinical diagnosis of idiopathic Parkinson's disease are treated with levodopa. Because there is no biological marker for the diagnosis, erroneous clinical diagnosis and treatment of such cases with levodopa are well known. There is very limited literature on levodopa treated cases that had normal substantia nigra at autopsy.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H" last="Rajput">Ali H. Rajput</name></noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L" last="Rajput">Michele L. Rajput</name><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A" last="Robinson">Christopher A. 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